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This review will cover the pharmacology and antimicrobial spectrum of antifungal drugs used in the systemic treatment of pulmonary fungal diseases, highlighting the clinical trial data supporting targeted treatment of specific disease entities. For severe cases, initial treatment with amphotericin b (preferably liposomal) for 2 to 4 weeks is recommended, followed by an azole for 9 to 12 months. Further clinical deterioration and lack of improvement in these cases suggest the initiation of empiric antifungal therapy.
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At the same time, empirical treatment is initiated on the basis of clinical suspicion and severity of illness, such as organ failure, septic shock, or multiple organ failure. The medications listed below are related to or used in the treatment of this condition See also best practices in management of fungal pneumonias
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Empiric treatment with voriconazole 6 mg/kg twice daily intravenously for 2 doses should be started immediately based on infectious disease society of america (idsa) guidelines
Alternate treatments include isavuconazole and liposomal amphotericin b. While traditionally antifungal therapy was limited to the use of amphotericin b, flucytosine, and a handful of clinically available azole agents, current pharmacologic treatment options include potent new azole compounds with extended antifungal activity, lipidformsofamphotericinb,andnewerantifungaldrugs,including the echinocandins. Fungal pneumonia is a lung infection caused by fungi It can be life threatening in immunocompromised patients
